TRIADELPHIA -- The three were staying in separate rooms at the Comfort Inn in Triadelphia.
According to Valley Grove Fire Chief Bob Young his department was initially called out around 9:30 a.m. Dec. 6 for a person suffering from seizures and shortness of breath.
Upon arrival two more people were discovered as also being sick.
Young said the problem happened due to the cold weather.
"Construction crews working at the hotel had put up a retaining sheet and torpedo heaters, over night, so that they would be able to continue working in the cold weather. The carbon monoxide then built up and seeped into rooms crews were working outside of," said Young.
Carbon monoxide is the nation's number one cause of poisoning deaths with about 3,800 fatalities each year.
Ohio Valley Medical Center Dr. Randy Engelman said a carbon monoxide detector could have avoided this problem.
Engelman said carbon monoxide poisoning can be deadly and the warning sign are few.
"Most of the symptoms start off with a headache, fatigue, dizziness. If you go outside and feel better when you come back in that's a big warning," said Engleman.
According to authorities, a small portion of the hotel had to be shut down, but the hotel is open.
Managers at Comfort Inn said they had no comment.